Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 747354..748129 Replicon chromosome
Accession NZ_LR890356
Organism Klebsiella pneumoniae isolate INF231-sc-2280121

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag JMV88_RS03740 Protein ID WP_004889762.1
Coordinates 747644..748129 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMV88_RS03735 Protein ID WP_004150912.1
Coordinates 747354..747647 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV88_RS03715 742563..743165 - 603 WP_004174410.1 short chain dehydrogenase -
JMV88_RS03720 743263..744174 + 912 WP_017879796.1 LysR family transcriptional regulator -
JMV88_RS03725 744175..745323 - 1149 WP_004889759.1 PLP-dependent aspartate aminotransferase family protein -
JMV88_RS03730 745334..746710 - 1377 WP_017879795.1 pyridoxal-phosphate dependent enzyme -
JMV88_RS03735 747354..747647 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMV88_RS03740 747644..748129 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
JMV88_RS03745 748833..749425 + 593 Protein_737 hypothetical protein -
JMV88_RS03750 749522..749738 + 217 Protein_738 transposase -
JMV88_RS03760 750253..750966 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 749522..749674 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T290747 WP_004889762.1 NZ_LR890356:747644-748129 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT290747 WP_004150912.1 NZ_LR890356:747354-747647 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References