Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 679675..680474 Replicon chromosome
Accession NZ_LR890349
Organism Escherichia coli isolate MSB1_9D-sc-2280338

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag JMW03_RS03265 Protein ID WP_000347251.1
Coordinates 679675..680139 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag JMW03_RS03270 Protein ID WP_001308975.1
Coordinates 680139..680474 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW03_RS03235 674676..675110 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JMW03_RS03240 675128..676006 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW03_RS03245 675996..676775 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW03_RS03250 676786..677259 - 474 WP_201514308.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW03_RS03255 677282..678562 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW03_RS03260 678811..679620 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW03_RS03265 679675..680139 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW03_RS03270 680139..680474 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW03_RS03275 680623..682194 - 1572 WP_201514310.1 galactarate dehydratase -
JMW03_RS03280 682569..683903 + 1335 WP_137471965.1 galactarate/glucarate/glycerate transporter GarP -
JMW03_RS03285 683919..684689 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T290732 WP_000347251.1 NZ_LR890349:c680139-679675 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT290732 WP_001308975.1 NZ_LR890349:c680474-680139 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References