Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2650555..2651354 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JMW07_RS12770 Protein ID WP_000347273.1
Coordinates 2650890..2651354 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag JMW07_RS12765 Protein ID WP_001308975.1
Coordinates 2650555..2650890 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS12750 2646340..2647110 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
JMW07_RS12755 2647126..2648460 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMW07_RS12760 2648835..2650406 + 1572 WP_023908830.1 galactarate dehydratase -
JMW07_RS12765 2650555..2650890 + 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW07_RS12770 2650890..2651354 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW07_RS12775 2651409..2652218 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW07_RS12780 2652467..2653747 + 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW07_RS12785 2653770..2654243 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW07_RS12790 2654254..2655033 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW07_RS12795 2655023..2655901 + 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW07_RS12800 2655919..2656353 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T290691 WP_000347273.1 NZ_LR890334:2650890-2651354 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT290691 WP_001308975.1 NZ_LR890334:2650555-2650890 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References