Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4285204..4286003 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JMV91_RS20835 Protein ID WP_000347273.1
Coordinates 4285539..4286003 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0TI39
Locus tag JMV91_RS20830 Protein ID WP_021547164.1
Coordinates 4285204..4285539 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS20815 4280989..4281759 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
JMV91_RS20820 4281775..4283109 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMV91_RS20825 4283484..4285055 + 1572 WP_001273756.1 galactarate dehydratase -
JMV91_RS20830 4285204..4285539 + 336 WP_021547164.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMV91_RS20835 4285539..4286003 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMV91_RS20840 4286058..4286867 - 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
JMV91_RS20845 4287116..4288396 + 1281 WP_000681958.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMV91_RS20850 4288419..4288892 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMV91_RS20855 4288903..4289682 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMV91_RS20860 4289672..4290550 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMV91_RS20865 4290568..4291002 + 435 WP_000948834.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4263475..4286003 22528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T290666 WP_000347273.1 NZ_LR890326:4285539-4286003 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12309.86 Da        Isoelectric Point: 4.5392

>AT290666 WP_021547164.1 NZ_LR890326:4285204-4285539 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB V0TI39

References