290656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1724526..1725028 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMV91_RS08210 Protein ID WP_000767829.1
Coordinates 1724774..1725028 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMV91_RS08205 Protein ID WP_001259255.1
Coordinates 1724526..1724777 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS08180 1719703..1720770 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMV91_RS08185 1720770..1721840 - 1071 WP_001099214.1 histidinol-phosphate transaminase -
JMV91_RS08190 1721837..1723141 - 1305 WP_001396164.1 histidinol dehydrogenase -
JMV91_RS08195 1723147..1724046 - 900 WP_000566782.1 ATP phosphoribosyltransferase -
JMV91_RS08200 1724192..1724242 - 51 WP_001364200.1 his operon leader peptide -
JMV91_RS08205 1724526..1724777 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMV91_RS08210 1724774..1725028 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMV91_RS08215 1725111..1725935 + 825 WP_000754754.1 SDR family oxidoreductase -
JMV91_RS08220 1725981..1726910 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMV91_RS08225 1727125..1727187 + 63 WP_010723108.1 membrane protein YoeI -
JMV91_RS08230 1727177..1728535 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMV91_RS08235 1728714..1729772 + 1059 WP_000492305.1 transport protein YeeE -
JMV91_RS08240 1729786..1730013 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290656 WP_000767829.1 NZ_LR890326:1724774-1725028 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290656 WP_001259255.1 NZ_LR890326:1724526-1724777 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References