Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1724526..1725028 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMV91_RS08210 Protein ID WP_000767829.1
Coordinates 1724774..1725028 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMV91_RS08205 Protein ID WP_001259255.1
Coordinates 1724526..1724777 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS08180 1719703..1720770 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMV91_RS08185 1720770..1721840 - 1071 WP_001099214.1 histidinol-phosphate transaminase -
JMV91_RS08190 1721837..1723141 - 1305 WP_001396164.1 histidinol dehydrogenase -
JMV91_RS08195 1723147..1724046 - 900 WP_000566782.1 ATP phosphoribosyltransferase -
JMV91_RS08200 1724192..1724242 - 51 WP_001364200.1 his operon leader peptide -
JMV91_RS08205 1724526..1724777 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMV91_RS08210 1724774..1725028 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMV91_RS08215 1725111..1725935 + 825 WP_000754754.1 SDR family oxidoreductase -
JMV91_RS08220 1725981..1726910 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMV91_RS08225 1727125..1727187 + 63 WP_010723108.1 membrane protein YoeI -
JMV91_RS08230 1727177..1728535 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMV91_RS08235 1728714..1729772 + 1059 WP_000492305.1 transport protein YeeE -
JMV91_RS08240 1729786..1730013 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290656 WP_000767829.1 NZ_LR890326:1724774-1725028 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290656 WP_001259255.1 NZ_LR890326:1724526-1724777 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References