Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 49658..50385 Replicon plasmid 2
Accession NZ_LR890308
Organism Klebsiella pneumoniae isolate INF188-sc-2280054

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LNL2
Locus tag JMW12_RS25725 Protein ID WP_004118600.1
Coordinates 49658..49969 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V0AHC4
Locus tag JMW12_RS25730 Protein ID WP_000990392.1
Coordinates 49966..50385 (+) Length 140 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW12_RS25705 46172..46891 + 720 WP_001102107.1 (Fe-S)-binding protein -
JMW12_RS25710 46902..48329 + 1428 WP_000023895.1 iron-sulfur cluster-binding protein -
JMW12_RS25715 48322..49017 + 696 WP_004118595.1 lactate utilization protein C -
JMW12_RS25720 49067..49447 - 381 Protein_44 gluconate permease -
JMW12_RS25725 49658..49969 + 312 WP_004118600.1 type II toxin-antitoxin system HigB family toxin Toxin
JMW12_RS25730 49966..50385 + 420 WP_000990392.1 helix-turn-helix domain-containing protein Antitoxin
JMW12_RS25735 50422..51624 - 1203 WP_003031541.1 hypothetical protein -
JMW12_RS25740 51617..51946 - 330 WP_004118613.1 hypothetical protein -
JMW12_RS25745 51943..52602 - 660 WP_000078540.1 hypothetical protein -
JMW12_RS25750 53026..53619 - 594 WP_044348674.1 hypothetical protein -
JMW12_RS25755 53935..54288 + 354 WP_001114073.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
JMW12_RS25760 54336..54698 + 363 WP_020324593.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 / blaLAP-2 / qnrS1 / catA2 / tet(D) / tet(A) / dfrA1 / qacE / sul1 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 - 1..263601 263601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12386.14 Da        Isoelectric Point: 10.0935

>T290601 WP_004118600.1 NZ_LR890308:49658-49969 [Klebsiella pneumoniae]
MHIVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE

Download         Length: 312 bp


Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15534.71 Da        Isoelectric Point: 4.4702

>AT290601 WP_000990392.1 NZ_LR890308:49966-50385 [Klebsiella pneumoniae]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA

Download         Length: 420 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5Q9LNL2


Antitoxin

Source ID Structure
AlphaFold DB V0AHC4

References