Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2441269..2441453 Replicon chromosome
Accession NC_020529
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAI1T1_RS15085 Protein ID WP_000482652.1
Coordinates 2441346..2441453 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2441269..2441329 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI1T1_RS15070 2436724..2436891 - 168 Protein_2327 hypothetical protein -
SAI1T1_RS12340 2437122..2438855 - 1734 WP_000486483.1 ABC transporter ATP-binding protein/permease -
SAI1T1_RS12345 2438880..2440643 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2441269..2441329 + 61 - - Antitoxin
SAI1T1_RS15085 2441346..2441453 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAI1T1_RS12360 2441587..2441973 - 387 WP_000779360.1 flippase GtxA -
SAI1T1_RS12365 2442241..2443383 + 1143 WP_001176863.1 glycerate kinase -
SAI1T1_RS12370 2443443..2444102 + 660 WP_000831302.1 hypothetical protein -
SAI1T1_RS12375 2444284..2445495 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAI1T1_RS12380 2445618..2446091 - 474 WP_015445934.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T29058 WP_000482652.1 NC_020529:c2441453-2441346 [Staphylococcus aureus subsp. aureus ST228]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T29058 NC_020529:c2441453-2441346 [Staphylococcus aureus subsp. aureus ST228]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT29058 NC_020529:2441269-2441329 [Staphylococcus aureus subsp. aureus ST228]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References