Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3960660..3961459 Replicon chromosome
Accession NZ_LR890299
Organism Escherichia coli isolate MSB1_3B-sc-2280406

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag JM188_RS18845 Protein ID WP_000347270.1
Coordinates 3960660..3961124 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag JM188_RS18850 Protein ID WP_001551693.1
Coordinates 3961124..3961459 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM188_RS18815 3955661..3956095 - 435 WP_000948837.1 PTS sugar transporter subunit IIA -
JM188_RS18820 3956113..3956991 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JM188_RS18825 3956981..3957760 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JM188_RS18830 3957771..3958244 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JM188_RS18835 3958267..3959547 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
JM188_RS18840 3959796..3960605 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JM188_RS18845 3960660..3961124 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JM188_RS18850 3961124..3961459 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JM188_RS18855 3961608..3963179 - 1572 WP_001273738.1 galactarate dehydratase -
JM188_RS18860 3963554..3964888 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JM188_RS18865 3964904..3965674 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T290565 WP_000347270.1 NZ_LR890299:c3961124-3960660 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT290565 WP_001551693.1 NZ_LR890299:c3961459-3961124 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References