Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 710678..711453 Replicon chromosome
Accession NZ_LR890291
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A331A5C5
Locus tag JMW65_RS03560 Protein ID WP_019704987.1
Coordinates 710968..711453 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW65_RS03555 Protein ID WP_004150912.1
Coordinates 710678..710971 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS03535 705887..706489 - 603 WP_004174410.1 short chain dehydrogenase -
JMW65_RS03540 706587..707498 + 912 WP_004181308.1 LysR family transcriptional regulator -
JMW65_RS03545 707499..708647 - 1149 WP_094645045.1 PLP-dependent aspartate aminotransferase family protein -
JMW65_RS03550 708658..710034 - 1377 WP_004217775.1 cystathionine beta-synthase -
JMW65_RS03555 710678..710971 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW65_RS03560 710968..711453 + 486 WP_019704987.1 GNAT family N-acetyltransferase Toxin
JMW65_RS03565 712151..712744 + 594 WP_004188553.1 hypothetical protein -
JMW65_RS03570 712841..713057 + 217 Protein_700 transposase -
JMW65_RS03580 714061..714774 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 712841..712993 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17572.56 Da        Isoelectric Point: 8.5111

>T290530 WP_019704987.1 NZ_LR890291:710968-711453 [Klebsiella pneumoniae]
MISAPEPLNAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT290530 WP_004150912.1 NZ_LR890291:710678-710971 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331A5C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References