Detailed information of TA system TA290509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4075552..4075964
• Replicon: chromosome
• Accession: NZ_LR890288
• Organism: Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: JMW08_RS19400
• Protein ID: WP_000132601.1
• Coordinates: 4075623..4075964 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4075552..4075628 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW08_RS19385	4071091..4072680	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
JMW08_RS19390	4072677..4074071	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
JMW08_RS19395	4074246..4075466	-	1221	WP_000343760.1	ISL3-like element ISKox3 family transposase	-
-	4075552..4075628	-	77	NuclAT_13	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_13	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_13	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_13	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_14	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_14	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_14	-	Antitoxin
-	4075552..4075628	-	77	NuclAT_14	-	Antitoxin
JMW08_RS19400	4075623..4075964	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
JMW08_RS19405	4076126..4077505	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JMW08_RS19410	4077505..4078551	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4074246..4090231	15985
	-	flank	IS/Tn	-	-	4074246..4075466	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T290509 WP_000132601.1 NZ_LR890288:4075623-4075964 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT290509 NZ_LR890288:c4075628-4075552 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin