Detailed information of TA system TA029050

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1988550..1988857
• Replicon: chromosome
• Accession: NC_020529
• Organism: Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAI1T1_RS15670
• Protein ID: WP_011447039.1
• Coordinates: 1988681..1988857 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1988550..1988689 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAI1T1_RS09840	1984116..1984295	+	180	WP_000669791.1	hypothetical protein	-
SAI1T1_RS14875	1984606..1984866	+	261	WP_001791826.1	hypothetical protein	-
SAI1T1_RS09855	1984919..1985269	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAI1T1_RS09860	1985780..1986115	-	336	Protein_1854	SH3 domain-containing protein	-
SAI1T1_RS09865	1986766..1987257	-	492	WP_000920038.1	staphylokinase	-
SAI1T1_RS09870	1987448..1988203	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAI1T1_RS09875	1988215..1988469	-	255	WP_000611512.1	phage holin	-
SAI1T1_RS14880	1988521..1988628	+	108	WP_031762631.1	hypothetical protein	-
-	1988550..1988689	+	140	NuclAT_0	-	Antitoxin
-	1988550..1988689	+	140	NuclAT_0	-	Antitoxin
-	1988550..1988689	+	140	NuclAT_0	-	Antitoxin
-	1988550..1988689	+	140	NuclAT_0	-	Antitoxin
SAI1T1_RS15670	1988681..1988857	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAI1T1_RS09890	1988966..1989739	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAI1T1_RS09895	1990112..1990486	-	375	WP_000340977.1	hypothetical protein	-
SAI1T1_RS09900	1990542..1990829	-	288	WP_001262621.1	hypothetical protein	-
SAI1T1_RS14885	1990875..1991027	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / groEL	1984919..2024450	39531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29050 WP_011447039.1 NC_020529:c1988857-1988681 [Staphylococcus aureus subsp. aureus ST228]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29050 NC_020529:c1988857-1988681 [Staphylococcus aureus subsp. aureus ST228]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29050 NC_020529:1988550-1988689 [Staphylococcus aureus subsp. aureus ST228]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin