290498

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1829495..1829997 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMW08_RS08670 Protein ID WP_000767829.1
Coordinates 1829743..1829997 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMW08_RS08665 Protein ID WP_001259255.1
Coordinates 1829495..1829746 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS08640 1824672..1825739 - 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMW08_RS08645 1825739..1826809 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
JMW08_RS08650 1826806..1828110 - 1305 WP_074514295.1 histidinol dehydrogenase -
JMW08_RS08655 1828116..1829015 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMW08_RS08660 1829161..1829211 - 51 WP_001364200.1 his operon leader peptide -
JMW08_RS08665 1829495..1829746 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW08_RS08670 1829743..1829997 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW08_RS08675 1830080..1830904 + 825 WP_000754737.1 SDR family oxidoreductase -
JMW08_RS08680 1830950..1831879 + 930 WP_000803366.1 LysR family transcriptional regulator -
JMW08_RS08685 1832094..1832156 + 63 WP_010723108.1 membrane protein YoeI -
JMW08_RS08690 1832146..1833504 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMW08_RS08695 1833683..1834741 + 1059 WP_087523589.1 transport protein YeeE -
JMW08_RS08700 1834755..1834982 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290498 WP_000767829.1 NZ_LR890288:1829743-1829997 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290498 WP_001259255.1 NZ_LR890288:1829495-1829746 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References