290494

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 729450..730143 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JMW08_RS03535 Protein ID WP_000415584.1
Coordinates 729450..729746 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JMW08_RS03540 Protein ID WP_000650107.1
Coordinates 729748..730143 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS03500 724538..724852 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
JMW08_RS03505 724883..725464 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JMW08_RS03510 725783..726115 + 333 WP_023149630.1 DUF2645 family protein -
JMW08_RS03515 726161..727510 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
JMW08_RS03520 727507..728166 - 660 WP_001221493.1 two-component system response regulator QseB -
JMW08_RS03525 728318..728710 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JMW08_RS03530 728763..729245 + 483 WP_000183505.1 transcriptional regulator -
JMW08_RS03535 729450..729746 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JMW08_RS03540 729748..730143 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JMW08_RS03545 730276..731883 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JMW08_RS03550 732021..734279 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T290494 WP_000415584.1 NZ_LR890288:729450-729746 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT290494 WP_000650107.1 NZ_LR890288:729748-730143 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References