290493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 622838..623637 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name yhaV Uniprot ID D3GWU5
Locus tag JMW08_RS03020 Protein ID WP_000347272.1
Coordinates 622838..623302 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JMW08_RS03025 Protein ID WP_001307405.1
Coordinates 623302..623637 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS02990 617839..618273 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JMW08_RS02995 618291..619169 - 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW08_RS03000 619159..619938 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW08_RS03005 619949..620422 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW08_RS03010 620445..621725 - 1281 WP_001521382.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW08_RS03015 621974..622783 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
JMW08_RS03020 622838..623302 - 465 WP_000347272.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW08_RS03025 623302..623637 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW08_RS03030 623786..625357 - 1572 WP_001273738.1 galactarate dehydratase -
JMW08_RS03035 625732..627066 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMW08_RS03040 627082..627852 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 622838..634290 11452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17832.26 Da        Isoelectric Point: 9.6924

>T290493 WP_000347272.1 NZ_LR890288:c623302-622838 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT290493 WP_001307405.1 NZ_LR890288:c623637-623302 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829KUD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References