Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 46498..47172 Replicon plasmid 2
Accession NZ_LR890278
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LMS5
Locus tag JMV94_RS25115 Protein ID WP_032720638.1
Coordinates 46498..46821 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV94_RS25120 Protein ID WP_032720637.1
Coordinates 46870..47172 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS25090 41524..41847 + 324 WP_019725650.1 hypothetical protein -
JMV94_RS25095 42318..43022 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
JMV94_RS25100 43182..44528 - 1347 WP_077251107.1 ISNCY family transposase -
JMV94_RS25105 44839..45441 + 603 Protein_49 transposase -
JMV94_RS25110 45768..46320 + 553 Protein_50 DUF4113 domain-containing protein -
JMV94_RS25115 46498..46821 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV94_RS25120 46870..47172 + 303 WP_032720637.1 helix-turn-helix domain-containing protein Antitoxin
JMV94_RS25125 47215..47382 - 168 WP_153591440.1 hypothetical protein -
JMV94_RS25130 47570..47749 - 180 WP_032720701.1 hypothetical protein -
JMV94_RS25135 47773..48156 - 384 WP_032720636.1 hypothetical protein -
JMV94_RS25140 48261..48833 - 573 WP_032720635.1 GNAT family N-acetyltransferase -
JMV94_RS25145 48835..49623 - 789 WP_032720700.1 TSUP family transporter -
JMV94_RS25150 49659..50579 - 921 WP_050548604.1 TauD/TfdA family dioxygenase -
JMV94_RS25155 50882..51376 - 495 WP_044266755.1 hypothetical protein -
JMV94_RS25160 51407..51979 - 573 WP_044266753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrB1 / dfrA14 / blaCTX-M-15 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B - 1..184852 184852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12372.29 Da        Isoelectric Point: 9.6240

>T290475 WP_032720638.1 NZ_LR890278:46498-46821 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK

Download         Length: 324 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11211.12 Da        Isoelectric Point: 7.3611

>AT290475 WP_032720637.1 NZ_LR890278:46870-47172 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LMS5

Antitoxin

Source ID Structure

References