290469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3716871..3717468 Replicon chromosome
Accession NZ_LR890277
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag JMV94_RS18230 Protein ID WP_004893639.1
Coordinates 3717151..3717468 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMV94_RS18225 Protein ID WP_004142561.1
Coordinates 3716871..3717158 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS18195 3712951..3713199 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMV94_RS18200 3713217..3713558 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMV94_RS18205 3713589..3714704 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMV94_RS18210 3714884..3715468 + 585 WP_002893026.1 TetR/AcrR family transcriptional regulator -
JMV94_RS18215 3715465..3715833 + 369 WP_002893024.1 MmcQ/YjbR family DNA-binding protein -
JMV94_RS18220 3715953..3716606 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMV94_RS18225 3716871..3717158 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMV94_RS18230 3717151..3717468 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV94_RS18235 3717653..3718696 - 1044 WP_021314069.1 DUF2157 domain-containing protein -
JMV94_RS18240 3719362..3720228 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMV94_RS18245 3720337..3721764 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T290469 WP_004893639.1 NZ_LR890277:c3717468-3717151 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT290469 WP_004142561.1 NZ_LR890277:c3717158-3716871 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References