Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 726939..727714 Replicon chromosome
Accession NZ_LR890277
Organism Klebsiella pneumoniae isolate INF355-sc-2280185

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag JMV94_RS03625 Protein ID WP_021314147.1
Coordinates 727229..727714 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMV94_RS03620 Protein ID WP_004150912.1
Coordinates 726939..727232 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV94_RS03600 722147..722749 - 603 WP_004174410.1 short chain dehydrogenase -
JMV94_RS03605 722847..723758 + 912 WP_201524319.1 LysR family transcriptional regulator -
JMV94_RS03610 723759..724907 - 1149 WP_020316731.1 PLP-dependent aspartate aminotransferase family protein -
JMV94_RS03615 724918..726294 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
JMV94_RS03620 726939..727232 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMV94_RS03625 727229..727714 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
JMV94_RS03630 728418..729011 + 594 WP_004188553.1 hypothetical protein -
JMV94_RS03635 729108..729324 + 217 Protein_712 transposase -
JMV94_RS03645 729839..730552 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 729108..729260 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T290462 WP_021314147.1 NZ_LR890277:727229-727714 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT290462 WP_004150912.1 NZ_LR890277:726939-727232 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References