29037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 684060..684637 Replicon chromosome
Accession NC_020528
Organism Sinorhizobium meliloti 2011

Toxin (Protein)


Gene name brnT Uniprot ID Q92S20
Locus tag SM2011_RS33385 Protein ID WP_010968707.1
Coordinates 684060..684323 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q92KN5
Locus tag SM2011_RS17450 Protein ID WP_010968708.1
Coordinates 684320..684637 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM2011_RS17410 679390..679830 + 441 WP_010968702.1 DUF2948 family protein -
SM2011_RS17415 679895..681199 + 1305 WP_010968703.1 histidinol dehydrogenase -
SM2011_RS17420 681196..681672 + 477 WP_010968704.1 UPF0262 family protein -
SM2011_RS17425 681686..682165 + 480 WP_010968705.1 low molecular weight phosphatase family protein -
SM2011_RS17430 682323..682541 + 219 WP_004435948.1 translation initiation factor IF-1 -
SM2011_RS17435 682639..683259 + 621 WP_004435951.1 Maf-like protein -
SM2011_RS17440 683264..683476 + 213 WP_010968706.1 DNA gyrase inhibitor YacG -
SM2011_RS33385 684060..684323 + 264 WP_010968707.1 BrnT family toxin Toxin
SM2011_RS17450 684320..684637 + 318 WP_010968708.1 BrnA antitoxin family protein Antitoxin
SM2011_RS17455 684840..685304 - 465 WP_013844019.1 type II toxin-antitoxin system HicB family antitoxin -
SM2011_RS33390 685301..685489 - 189 WP_013844020.1 hypothetical protein -
SM2011_RS17460 685809..686909 + 1101 WP_010968710.1 hypothetical protein -
SM2011_RS17465 686896..687978 + 1083 WP_010968711.1 nucleotidyltransferase family protein -
SM2011_RS17470 688181..688492 + 312 WP_004435964.1 hypothetical protein -
SM2011_RS17480 688772..689161 - 390 WP_010968712.1 DUF930 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 652923..685489 32566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(26-103)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9821.16 Da        Isoelectric Point: 10.3413

>T29037 WP_010968707.1 NC_020528:684060-684323 [Sinorhizobium meliloti 2011]
MRIVWGEPKRRANLEKHGFDFADVSDLDWASALIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP

Download         Length: 264 bp

>T29037 NC_020528:684060-684323 [Sinorhizobium meliloti 2011]
ATGCGAATTGTGTGGGGCGAACCCAAACGGCGAGCCAACCTTGAGAAGCATGGTTTCGATTTTGCCGATGTAAGCGACCT
CGATTGGGCGAGTGCCCTCATAGAGGACAGCAAGCCAGATACTTCTGGCAGAAAGCGCCTGAAGGCTATCGGTTATTTTC
GTGACGGGACGGCAGCGGTCATTTTCGCGACACTCGGAACGGAAGCTATATCGATCATCAGCTTTCGTCCTGCAAGCGAC
AGAGAAAGAAGGAGGCTTCCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12197.83 Da        Isoelectric Point: 10.0883

>AT29037 WP_010968708.1 NC_020528:684320-684637 [Sinorhizobium meliloti 2011]
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI

Download         Length: 318 bp

>AT29037 NC_020528:684320-684637 [Sinorhizobium meliloti 2011]
ATGACTACCAGGACCCGAAAATCGAAAACGTTCGAGCCAGGTCACGGCTATACAAAAGAGGAATGGGATGCAGTCGATTT
TCCCGAGTTGACCGATGAAGAGCTTACCAACATGCGTCCCGCGAGAGATGTGCTGCCGCCTGAGTTTTTCAAAGCTATGG
AGGAGCATCGCAGATCGCGTGGGCGCCCCTCGCTGGAGCATCCGAAAAAGCAAGTCACCCTCCGGTTGGACGAAGACGTG
ATCGCTAAGTTTCGAGCTGGTGGCAAAGGCTGGCAGAGCCGGATGAATGAGGCGCTGCGAAAAGCTGCAGGTATATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92S20

Antitoxin

Source ID Structure
AlphaFold DB Q92KN5

References