Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350848..351494 Replicon chromosome
Accession NZ_LR890235
Organism Klebsiella pneumoniae isolate INF334-sc-2280143

Toxin (Protein)


Gene name higB Uniprot ID A0A486UPU4
Locus tag JMV98_RS01615 Protein ID WP_032417639.1
Coordinates 350848..351195 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag JMV98_RS01620 Protein ID WP_002920557.1
Coordinates 351195..351494 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV98_RS01605 346774..348207 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMV98_RS01610 348225..350672 + 2448 WP_002920561.1 glycogen phosphorylase -
JMV98_RS01615 350848..351195 + 348 WP_032417639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV98_RS01620 351195..351494 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
JMV98_RS01625 351557..353065 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
JMV98_RS01630 353270..353599 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMV98_RS01635 353650..354480 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JMV98_RS01640 354530..355288 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13527.52 Da        Isoelectric Point: 5.6802

>T290357 WP_032417639.1 NZ_LR890235:350848-351195 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKELITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT290357 WP_002920557.1 NZ_LR890235:351195-351494 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486UPU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References