Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3799709..3800306 Replicon chromosome
Accession NZ_LR890217
Organism Klebsiella pneumoniae isolate INF357-sc-2280189

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMV73_RS18580 Protein ID WP_101971099.1
Coordinates 3799989..3800306 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMV73_RS18575 Protein ID WP_004142561.1
Coordinates 3799709..3799996 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV73_RS18545 3795789..3796037 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMV73_RS18550 3796055..3796396 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMV73_RS18555 3796427..3797542 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
JMV73_RS18560 3797722..3798306 + 585 WP_002893026.1 TetR/AcrR family transcriptional regulator -
JMV73_RS18565 3798303..3798671 + 369 WP_002893024.1 MmcQ/YjbR family DNA-binding protein -
JMV73_RS18570 3798791..3799444 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMV73_RS18575 3799709..3799996 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMV73_RS18580 3799989..3800306 - 318 WP_101971099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV73_RS18585 3800491..3801534 - 1044 WP_087761125.1 DUF2157 domain-containing protein -
JMV73_RS18590 3802200..3803066 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMV73_RS18595 3803175..3804602 + 1428 WP_004223482.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12076.37 Da        Isoelectric Point: 11.2767

>T290332 WP_101971099.1 NZ_LR890217:c3800306-3799989 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLLLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT290332 WP_004142561.1 NZ_LR890217:c3799996-3799709 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References