Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 361282..361928 Replicon chromosome
Accession NZ_LR890209
Organism Klebsiella pneumoniae isolate INF022-sc-2279895

Toxin (Protein)


Gene name higB Uniprot ID A0A2V3KK24
Locus tag JMW18_RS01690 Protein ID WP_032731351.1
Coordinates 361282..361629 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag JMW18_RS01695 Protein ID WP_008806992.1
Coordinates 361629..361928 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW18_RS01680 357169..358602 + 1434 WP_004202133.1 glycogen synthase GlgA -
JMW18_RS01685 358620..361067 + 2448 WP_008806990.1 glycogen phosphorylase -
JMW18_RS01690 361282..361629 + 348 WP_032731351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW18_RS01695 361629..361928 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
JMW18_RS01700 361991..363499 - 1509 WP_023298298.1 glycerol-3-phosphate dehydrogenase -
JMW18_RS01705 363704..364033 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
JMW18_RS01710 364084..364914 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
JMW18_RS01715 364964..365722 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13474.43 Da        Isoelectric Point: 6.2327

>T290309 WP_032731351.1 NZ_LR890209:361282-361629 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT290309 WP_008806992.1 NZ_LR890209:361629-361928 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KK24

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References