Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2372517..2373206 Replicon chromosome
Accession NZ_LR890204
Organism Klebsiella pneumoniae isolate INF277

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag JMW21_RS11585 Protein ID WP_021469727.1
Coordinates 2372517..2372834 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW21_RS11590 Protein ID WP_040147778.1
Coordinates 2372910..2373206 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW21_RS11555 2368219..2368728 + 510 WP_002906702.1 GNAT family N-acetyltransferase -
JMW21_RS11560 2368738..2369664 + 927 WP_032416224.1 amino acid ABC transporter permease -
JMW21_RS11565 2369648..2370427 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
JMW21_RS11570 2370466..2371317 + 852 WP_014343117.1 transporter substrate-binding domain-containing protein -
JMW21_RS11575 2371395..2372012 + 618 WP_040147782.1 glutathione S-transferase family protein -
JMW21_RS11580 2372083..2372310 + 228 WP_002906690.1 tautomerase PptA -
JMW21_RS11585 2372517..2372834 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW21_RS11590 2372910..2373206 + 297 WP_040147778.1 helix-turn-helix domain-containing protein Antitoxin
JMW21_RS11595 2373285..2373731 + 447 WP_004175959.1 hypothetical protein -
JMW21_RS11600 2373772..2375388 - 1617 WP_040147777.1 carbohydrate porin -
JMW21_RS11605 2375432..2376814 - 1383 WP_099743292.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T290298 WP_021469727.1 NZ_LR890204:2372517-2372834 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11032.88 Da        Isoelectric Point: 6.4721

>AT290298 WP_040147778.1 NZ_LR890204:2372910-2373206 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMPMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRQPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References