Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4298464..4299110 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name higB Uniprot ID A6TF46
Locus tag JMV80_RS20700 Protein ID WP_015959099.1
Coordinates 4298464..4298811 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag JMV80_RS20705 Protein ID WP_004174017.1
Coordinates 4298811..4299110 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS20690 4294390..4295823 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMV80_RS20695 4295841..4298288 + 2448 WP_002920561.1 glycogen phosphorylase -
JMV80_RS20700 4298464..4298811 + 348 WP_015959099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV80_RS20705 4298811..4299110 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
JMV80_RS20710 4299173..4300681 - 1509 WP_015959098.1 glycerol-3-phosphate dehydrogenase -
JMV80_RS20715 4300886..4301215 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMV80_RS20720 4301266..4302096 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JMV80_RS20725 4302146..4302904 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13519.49 Da        Isoelectric Point: 6.2327

>T290288 WP_015959099.1 NZ_LR890202:4298464-4298811 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMNTLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT290288 WP_004174017.1 NZ_LR890202:4298811-4299110 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TF46

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References