Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2479882..2480479 Replicon chromosome
Accession NZ_LR890202
Organism Klebsiella pneumoniae isolate INF008-sc-2279879

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JMV80_RS12075 Protein ID WP_004142563.1
Coordinates 2480162..2480479 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMV80_RS12070 Protein ID WP_004142561.1
Coordinates 2479882..2480169 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV80_RS12040 2475962..2476210 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMV80_RS12045 2476228..2476569 - 342 WP_169555045.1 RamA family antibiotic efflux transcriptional regulator -
JMV80_RS12050 2476600..2477715 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMV80_RS12055 2477895..2478476 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JMV80_RS12060 2478476..2478844 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JMV80_RS12065 2478964..2479617 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMV80_RS12070 2479882..2480169 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMV80_RS12075 2480162..2480479 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV80_RS12080 2480664..2481707 - 1044 WP_048336957.1 DUF2157 domain-containing protein -
JMV80_RS12085 2482373..2483239 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMV80_RS12090 2483348..2484775 + 1428 WP_023300814.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T290281 WP_004142563.1 NZ_LR890202:c2480479-2480162 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT290281 WP_004142561.1 NZ_LR890202:c2480169-2479882 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References