Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 12447..13093 Replicon plasmid 4
Accession NZ_LR890201
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMV89_RS25645 Protein ID WP_096956853.1
Coordinates 12743..13093 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID E9TBD4
Locus tag JMV89_RS25640 Protein ID WP_001259442.1
Coordinates 12447..12746 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS25600 7815..8123 + 309 WP_000447215.1 hypothetical protein -
JMV89_RS25605 8189..8839 + 651 WP_201520209.1 hypothetical protein -
JMV89_RS25610 9050..9535 + 486 WP_001061740.1 hypothetical protein -
JMV89_RS25615 10113..10337 + 225 WP_050418674.1 hypothetical protein -
JMV89_RS25620 10370..10720 + 351 WP_000694583.1 hypothetical protein -
JMV89_RS25625 11040..11663 + 624 WP_001127156.1 ParA family protein -
JMV89_RS25630 11660..11869 + 210 WP_096956855.1 hypothetical protein -
JMV89_RS25635 11898..12389 + 492 WP_000456858.1 hypothetical protein -
JMV89_RS25640 12447..12746 - 300 WP_001259442.1 XRE family transcriptional regulator Antitoxin
JMV89_RS25645 12743..13093 - 351 WP_096956853.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV89_RS25650 13451..13954 + 504 WP_021526598.1 hypothetical protein -
JMV89_RS25655 14123..14491 + 369 WP_001330915.1 hypothetical protein -
JMV89_RS25660 15059..15655 - 597 WP_021528077.1 hypothetical protein -
JMV89_RS25665 15652..16179 - 528 WP_001330917.1 hypothetical protein -
JMV89_RS25670 16191..16406 + 216 WP_001280801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29794 29794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13769.84 Da        Isoelectric Point: 8.9197

>T290273 WP_096956853.1 NZ_LR890201:c13093-12743 [Escherichia coli]
MWTVYFGRLFDEWFEEQELALKRKVLAELRHLEKFGPSLSRPHADTVKGSRHKNMKELRIQYEGHPIRAFFAFDPIRQAI
ILCAGDKSNDKKFYDRMIRIADEEFSTHLAELEGKK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10931.73 Da        Isoelectric Point: 4.6283

>AT290273 WP_001259442.1 NZ_LR890201:c12746-12447 [Escherichia coli]
MRTLEEVIAAQSPESQAIIKAMADEMILETGLQMMREELQLSQKQVADAMGISQPAVTQLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRIAFNI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E9TBD4

References