Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4878072..4878674 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag JMV89_RS23215 Protein ID WP_000897302.1
Coordinates 4878363..4878674 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV89_RS23210 Protein ID WP_000356397.1
Coordinates 4878072..4878362 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS23185 4874145..4875047 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
JMV89_RS23190 4875044..4875679 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JMV89_RS23195 4875676..4876605 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
JMV89_RS23200 4876821..4877039 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
JMV89_RS23205 4877435..4877713 - 279 WP_001296612.1 hypothetical protein -
JMV89_RS23210 4878072..4878362 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JMV89_RS23215 4878363..4878674 - 312 WP_000897302.1 hypothetical protein Toxin
JMV89_RS23220 4878903..4879811 + 909 WP_001331553.1 alpha/beta hydrolase -
JMV89_RS23225 4879875..4880816 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JMV89_RS23230 4880861..4881298 - 438 WP_000560990.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMV89_RS23235 4881295..4882167 - 873 WP_000920762.1 virulence factor BrkB family protein -
JMV89_RS23240 4882161..4882760 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T290262 WP_000897302.1 NZ_LR890198:c4878674-4878363 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT290262 WP_000356397.1 NZ_LR890198:c4878362-4878072 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References