Detailed information of TA system TA029026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2864..3515
• Replicon: plasmid pD1279779
• Accession: NC_020525
• Organism: Acinetobacter baumannii D1279779

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8YFZ1
• Locus tag: ABD1_RS17585
• Protein ID: WP_000269904.1
• Coordinates: 2864..3220 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ABD1_RS17590
• Protein ID: WP_001129974.1
• Coordinates: 3213..3515 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABD1_RS17570	145..1068	+	924	WP_000845851.1	replication initiation protein RepM	-
ABD1_RS17575	1136..1681	+	546	WP_000736775.1	plasmid replication DNA-binding protein	-
ABD1_RS17580	2019..2336	+	318	WP_000900860.1	hypothetical protein	-
ABD1_RS17585	2864..3220	+	357	WP_000269904.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABD1_RS17590	3213..3515	+	303	WP_001129974.1	XRE family transcriptional regulator	Antitoxin
ABD1_RS17595	3508..3717	+	210	WP_000069475.1	hypothetical protein	-
ABD1_RS17600	3892..4410	+	519	WP_000447195.1	sel1 repeat family protein	-
ABD1_RS17605	4449..4961	+	513	WP_001089574.1	SMI1/KNR4 family protein	-
ABD1_RS17610	5160..5954	+	795	WP_000497472.1	hypothetical protein	-
ABD1_RS17615	6001..6192	-	192	WP_000102616.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..7416	7416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-81)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13488.42 Da
• Isoelectric Point: 5.7104

>T29026 WP_000269904.1 NC_020525:2864-3220 [Acinetobacter baumannii D1279779]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T29026 NC_020525:2864-3220 [Acinetobacter baumannii D1279779]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11150.97 Da
• Isoelectric Point: 7.3198

>AT29026 WP_001129974.1 NC_020525:3213-3515 [Acinetobacter baumannii D1279779]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT29026 NC_020525:3213-3515 [Acinetobacter baumannii D1279779]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: N8YFZ1