Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2631513..2632066 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name higB Uniprot ID A0A0G9FUJ7
Locus tag JMV89_RS12455 Protein ID WP_000605680.1
Coordinates 2631513..2631782 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag JMV89_RS12460 Protein ID WP_000781370.1
Coordinates 2631782..2632066 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS12430 2627099..2627530 - 432 WP_000152305.1 peroxiredoxin OsmC -
JMV89_RS12435 2627875..2628090 + 216 WP_000495766.1 biofilm-dependent modulation protein -
JMV89_RS12440 2628192..2628329 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
JMV89_RS12445 2628486..2630183 + 1698 WP_000433464.1 malate dehydrogenase -
JMV89_RS12450 2630317..2631327 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
JMV89_RS12455 2631513..2631782 + 270 WP_000605680.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV89_RS12460 2631782..2632066 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
JMV89_RS12465 2632295..2632948 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
JMV89_RS12470 2632941..2633825 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
JMV89_RS12475 2633838..2636885 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10181.73 Da        Isoelectric Point: 6.8582

>T290253 WP_000605680.1 NZ_LR890198:2631513-2631782 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVNGDA
YILDYEDYH

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT290253 WP_000781370.1 NZ_LR890198:2631782-2632066 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9FUJ7

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References