Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1981615..1982117 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name yoeB Uniprot ID D8A584
Locus tag JMV89_RS09320 Protein ID WP_000767828.1
Coordinates 1981863..1982117 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMV89_RS09315 Protein ID WP_001259255.1
Coordinates 1981615..1981866 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS09290 1976793..1977860 - 1068 WP_000080129.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMV89_RS09295 1977860..1978930 - 1071 WP_000108949.1 histidinol-phosphate transaminase -
JMV89_RS09300 1978927..1980231 - 1305 WP_001370829.1 histidinol dehydrogenase -
JMV89_RS09305 1980237..1981136 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMV89_RS09310 1981282..1981332 - 51 WP_001364200.1 his operon leader peptide -
JMV89_RS09315 1981615..1981866 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMV89_RS09320 1981863..1982117 + 255 WP_000767828.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMV89_RS09325 1982200..1983024 + 825 WP_000754740.1 SDR family oxidoreductase -
JMV89_RS09330 1983070..1983999 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMV89_RS09335 1984214..1984276 + 63 WP_010723108.1 membrane protein YoeI -
JMV89_RS09340 1984266..1985624 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMV89_RS09345 1985803..1986861 + 1059 WP_000492324.1 transport protein YeeE -
JMV89_RS09350 1986875..1987102 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.56 Da        Isoelectric Point: 8.0353

>T290246 WP_000767828.1 NZ_LR890198:1981863-1982117 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290246 WP_001259255.1 NZ_LR890198:1981615-1981866 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G465

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References