Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600746..601545 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag JMV89_RS02915 Protein ID WP_000347251.1
Coordinates 600746..601210 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag JMV89_RS02920 Protein ID WP_001296435.1
Coordinates 601210..601545 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS02885 595747..596181 - 435 WP_000948834.1 PTS sugar transporter subunit IIA -
JMV89_RS02890 596199..597077 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMV89_RS02895 597067..597846 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMV89_RS02900 597857..598330 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMV89_RS02905 598353..599633 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMV89_RS02910 599882..600691 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMV89_RS02915 600746..601210 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMV89_RS02920 601210..601545 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMV89_RS02925 601694..603265 - 1572 WP_001273939.1 galactarate dehydratase -
JMV89_RS02930 603640..604974 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
JMV89_RS02935 604990..605760 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T290242 WP_000347251.1 NZ_LR890198:c601210-600746 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT290242 WP_001296435.1 NZ_LR890198:c601545-601210 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References