Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349018..349664 Replicon chromosome
Accession NZ_LR890189
Organism Klebsiella pneumoniae isolate INF133-sc-2279960

Toxin (Protein)


Gene name higB Uniprot ID A0A332YAY3
Locus tag JMX29_RS01600 Protein ID WP_032435150.1
Coordinates 349018..349365 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag JMX29_RS01605 Protein ID WP_002920557.1
Coordinates 349365..349664 (+) Length 100 a.a.

Genomic Context


JMX29_RS01590JMX29_RS01595JMX29_RS01600JMX29_RS01605JMX29_RS01615JMX29_RS01620JMX29_RS01625JMX29_RS01610
Location: 344944..346377 (1434 bp)
Type: Others
Protein ID: WP_002920564.1
Location: 346395..348842 (2448 bp)
Type: Others
Protein ID: WP_002920561.1
Location: 349018..349365 (348 bp)
Type: Toxin
Protein ID: WP_032435150.1
Location: 349365..349664 (300 bp)
Type: Antitoxin
Protein ID: WP_002920557.1
Location: 351440..351769 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Location: 351820..352650 (831 bp)
Type: Others
Protein ID: WP_004151408.1
Location: 352700..353458 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Location: 349727..351235 (1509 bp)
Type: Others
Protein ID: WP_002920554.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JMX29_RS01590344944..346377+1434WP_002920564.1glycogen synthase GlgA-
JMX29_RS01595346395..348842+2448WP_002920561.1glycogen phosphorylase-
JMX29_RS01600349018..349365+348WP_032435150.1type II toxin-antitoxin system RelE/ParE family toxinToxin
JMX29_RS01605349365..349664+300WP_002920557.1helix-turn-helix transcriptional regulatorAntitoxin
JMX29_RS01610349727..351235-1509WP_002920554.1glycerol-3-phosphate dehydrogenase-
JMX29_RS01615351440..351769+330WP_002920552.1thiosulfate sulfurtransferase GlpE-
JMX29_RS01620351820..352650+831WP_004151408.1rhomboid family intramembrane serine protease GlpG-
JMX29_RS01625352700..353458+759WP_002920548.1DeoR/GlpR family transcriptional regulator-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(9-87)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13531.52 Da        Isoelectric Point: 5.6749

>T290225 WP_032435150.1 NZ_LR890189:349018-349365 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp


Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT290225 WP_002920557.1 NZ_LR890189:349365-349664 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A332YAY3


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E1CBF8

References