Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2782282..2782884 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag JMV10_RS13185 Protein ID WP_000897305.1
Coordinates 2782573..2782884 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV10_RS13180 Protein ID WP_000356397.1
Coordinates 2782282..2782572 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS13155 2778207..2779109 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
JMV10_RS13160 2779106..2779741 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JMV10_RS13165 2779738..2780667 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
JMV10_RS13170 2780997..2781239 - 243 WP_001087409.1 hypothetical protein -
JMV10_RS13175 2781459..2781677 - 219 WP_001315930.1 ribbon-helix-helix domain-containing protein -
JMV10_RS13180 2782282..2782572 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JMV10_RS13185 2782573..2782884 - 312 WP_000897305.1 hypothetical protein Toxin
JMV10_RS13190 2783113..2784021 + 909 WP_001162704.1 alpha/beta hydrolase -
JMV10_RS13195 2784085..2785026 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JMV10_RS13200 2785071..2785508 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMV10_RS13205 2785505..2786377 - 873 WP_000920762.1 virulence factor BrkB family protein -
JMV10_RS13210 2786371..2786970 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T290177 WP_000897305.1 NZ_LR883965:c2782884-2782573 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT290177 WP_000356397.1 NZ_LR883965:c2782572-2782282 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References