Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 107604..108106 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMV10_RS00515 Protein ID WP_000767829.1
Coordinates 107852..108106 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMV10_RS00510 Protein ID WP_001259255.1
Coordinates 107604..107855 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS00485 102782..103849 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMV10_RS00490 103849..104919 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
JMV10_RS00495 104916..106220 - 1305 WP_001542955.1 histidinol dehydrogenase -
JMV10_RS00500 106226..107125 - 900 WP_021544710.1 ATP phosphoribosyltransferase -
JMV10_RS00505 107271..107321 - 51 WP_001364200.1 his operon leader peptide -
JMV10_RS00510 107604..107855 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMV10_RS00515 107852..108106 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMV10_RS00520 108189..109013 + 825 WP_000754737.1 SDR family oxidoreductase -
JMV10_RS00525 109059..109988 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMV10_RS00530 110203..110265 + 63 WP_010723108.1 membrane protein YoeI -
JMV10_RS00535 110255..111613 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290165 WP_000767829.1 NZ_LR883965:107852-108106 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290165 WP_001259255.1 NZ_LR883965:107604-107855 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References