Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3850212..3850753 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag JLZ95_RS18775 Protein ID WP_000615976.1
Coordinates 3850475..3850753 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JLZ95_RS18770 Protein ID WP_000729704.1
Coordinates 3850212..3850472 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS18750 3845887..3846672 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
JLZ95_RS18755 3846644..3848356 + 1713 Protein_3671 flagellar biosynthesis protein FlhA -
JLZ95_RS18760 3848580..3849077 - 498 WP_000006242.1 REP-associated tyrosine transposase RayT -
JLZ95_RS18765 3849253..3850026 - 774 WP_016245244.1 C40 family peptidase -
JLZ95_RS18770 3850212..3850472 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JLZ95_RS18775 3850475..3850753 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JLZ95_RS18780 3850909..3851649 + 741 WP_001727406.1 murein L,D-transpeptidase -
JLZ95_RS18785 3851620..3852387 - 768 WP_001365365.1 class II glutamine amidotransferase -
JLZ95_RS18790 3852593..3853171 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T290135 WP_000615976.1 NZ_LR883012:3850475-3850753 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT290135 WP_000729704.1 NZ_LR883012:3850212-3850472 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References