Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1902689..1903191 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JLZ95_RS09060 Protein ID WP_000767829.1
Coordinates 1902937..1903191 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JLZ95_RS09055 Protein ID WP_001259255.1
Coordinates 1902689..1902940 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS09030 1897867..1898934 - 1068 WP_000080145.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JLZ95_RS09035 1898934..1900004 - 1071 WP_000108954.1 histidinol-phosphate transaminase -
JLZ95_RS09040 1900007..1901305 - 1299 WP_001735396.1 histidinol dehydrogenase -
JLZ95_RS09045 1901311..1902210 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JLZ95_RS09050 1902356..1902406 - 51 WP_001364200.1 his operon leader peptide -
JLZ95_RS09055 1902689..1902940 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JLZ95_RS09060 1902937..1903191 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JLZ95_RS09065 1903274..1904098 + 825 WP_000754737.1 SDR family oxidoreductase -
JLZ95_RS09070 1904144..1905073 + 930 WP_000803337.1 LysR family transcriptional regulator -
JLZ95_RS09075 1905288..1905350 + 63 WP_010723108.1 membrane protein YoeI -
JLZ95_RS09080 1905340..1906698 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JLZ95_RS09085 1906877..1907935 + 1059 WP_000492340.1 transport protein YeeE -
JLZ95_RS09090 1907949..1908176 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290126 WP_000767829.1 NZ_LR883012:1902937-1903191 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290126 WP_001259255.1 NZ_LR883012:1902689-1902940 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References