Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 631825..632624 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JLZ95_RS03040 Protein ID WP_000347273.1
Coordinates 631825..632289 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag JLZ95_RS03045 Protein ID WP_005762317.1
Coordinates 632289..632624 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS03010 626826..627260 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
JLZ95_RS03015 627278..628156 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JLZ95_RS03020 628146..628925 - 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JLZ95_RS03025 628936..629409 - 474 WP_001735764.1 PTS N-acetylgalactosamine transporter subunit IIB -
JLZ95_RS03030 629432..630712 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JLZ95_RS03035 630961..631770 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JLZ95_RS03040 631825..632289 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JLZ95_RS03045 632289..632624 - 336 WP_005762317.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JLZ95_RS03050 632773..634344 - 1572 WP_001273753.1 galactarate dehydratase -
JLZ95_RS03055 634719..636038 + 1320 WP_001735763.1 galactarate/glucarate/glycerate transporter GarP -
JLZ95_RS03060 636054..636824 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T290121 WP_000347273.1 NZ_LR883012:c632289-631825 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.91 Da        Isoelectric Point: 4.8616

>AT290121 WP_005762317.1 NZ_LR883012:c632624-632289 [Escherichia coli]
MPANARSHAVLTSESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References