Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4777712..4778314 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag JL014_RS23215 Protein ID WP_000897305.1
Coordinates 4778003..4778314 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JL014_RS23210 Protein ID WP_000356397.1
Coordinates 4777712..4778002 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS23185 4773638..4774540 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
JL014_RS23190 4774537..4775172 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JL014_RS23195 4775169..4776098 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
JL014_RS23200 4776428..4776670 - 243 WP_001086388.1 hypothetical protein -
JL014_RS23205 4776889..4777107 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
JL014_RS23210 4777712..4778002 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JL014_RS23215 4778003..4778314 - 312 WP_000897305.1 hypothetical protein Toxin
JL014_RS23220 4778543..4779451 + 909 WP_001162704.1 alpha/beta hydrolase -
JL014_RS23225 4779515..4780456 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JL014_RS23230 4780501..4780938 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
JL014_RS23235 4780935..4781807 - 873 WP_000920762.1 virulence factor BrkB family protein -
JL014_RS23240 4781801..4782400 - 600 WP_001295269.1 glucose-1-phosphatase -
JL014_RS23245 4782499..4783284 - 786 WP_001662158.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T290116 WP_000897305.1 NZ_LR883006:c4778314-4778003 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT290116 WP_000356397.1 NZ_LR883006:c4778002-4777712 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References