Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4251598..4252010 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name symE Uniprot ID A0A3W4M8W4
Locus tag JL014_RS20735 Protein ID WP_000132864.1
Coordinates 4251669..4252010 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4251598..4251674 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS20725 4248542..4250131 + 1590 WP_001063214.1 type I restriction-modification system methyltransferase -
JL014_RS20730 4250128..4251441 + 1314 WP_000042302.1 restriction endonuclease subunit S -
- 4251598..4251674 - 77 NuclAT_14 - Antitoxin
- 4251598..4251674 - 77 NuclAT_14 - Antitoxin
- 4251598..4251674 - 77 NuclAT_14 - Antitoxin
- 4251598..4251674 - 77 NuclAT_14 - Antitoxin
- 4251598..4251674 - 77 NuclAT_15 - Antitoxin
- 4251598..4251674 - 77 NuclAT_15 - Antitoxin
- 4251598..4251674 - 77 NuclAT_15 - Antitoxin
- 4251598..4251674 - 77 NuclAT_15 - Antitoxin
JL014_RS20735 4251669..4252010 + 342 WP_000132864.1 endoribonuclease SymE Toxin
JL014_RS20740 4252053..4256912 - 4860 Protein_4054 DUF1998 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12254.06 Da        Isoelectric Point: 7.8817

>T290111 WP_000132864.1 NZ_LR883006:4251669-4252010 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT290111 NZ_LR883006:c4251674-4251598 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W4M8W4

Antitoxin

Download structure file

References