Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/- |
| Location | 1711739..1712241 | Replicon | chromosome |
| Accession | NC_020518 | ||
| Organism | Escherichia coli str. K-12 substr. MDS42 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | ECMDS42_RS08370 | Protein ID | WP_000767829.1 |
| Coordinates | 1711739..1711993 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | ECMDS42_RS08375 | Protein ID | WP_001259255.1 |
| Coordinates | 1711990..1712241 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECMDS42_RS08345 (ECMDS42_1625) | 1706754..1706981 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| ECMDS42_RS08350 (ECMDS42_1626) | 1706995..1708053 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| ECMDS42_RS08355 (ECMDS42_1627) | 1708232..1709590 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| ECMDS42_RS20800 | 1709580..1709642 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| ECMDS42_RS08360 (ECMDS42_1628) | 1709857..1710786 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| ECMDS42_RS08365 (ECMDS42_1629) | 1710832..1711656 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| ECMDS42_RS08370 (ECMDS42_1630) | 1711739..1711993 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| ECMDS42_RS08375 (ECMDS42_1631) | 1711990..1712241 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| ECMDS42_RS20025 (ECMDS42_1632) | 1712524..1712574 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| ECMDS42_RS08380 (ECMDS42_1633) | 1712720..1713619 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| ECMDS42_RS08385 (ECMDS42_1634) | 1713625..1714929 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| ECMDS42_RS08390 (ECMDS42_1635) | 1714926..1715996 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| ECMDS42_RS08395 (ECMDS42_1636) | 1715996..1717063 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T29011 WP_000767829.1 NC_020518:c1711993-1711739 [Escherichia coli str. K-12 substr. MDS42]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T29011 NC_020518:c1711993-1711739 [Escherichia coli str. K-12 substr. MDS42]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT29011 WP_001259255.1 NC_020518:c1712241-1711990 [Escherichia coli str. K-12 substr. MDS42]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT29011 NC_020518:c1712241-1711990 [Escherichia coli str. K-12 substr. MDS42]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|