Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1890038..1890540 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JL014_RS09085 Protein ID WP_000767829.1
Coordinates 1890286..1890540 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JL014_RS09080 Protein ID WP_001259255.1
Coordinates 1890038..1890289 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS09055 1885216..1886283 - 1068 WP_000080077.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JL014_RS09060 1886283..1887353 - 1071 WP_001099220.1 histidinol-phosphate transaminase -
JL014_RS09065 1887350..1888654 - 1305 WP_001355813.1 histidinol dehydrogenase -
JL014_RS09070 1888660..1889559 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JL014_RS09075 1889705..1889755 - 51 WP_001364200.1 his operon leader peptide -
JL014_RS09080 1890038..1890289 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JL014_RS09085 1890286..1890540 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JL014_RS09090 1890623..1891447 + 825 WP_000754737.1 SDR family oxidoreductase -
JL014_RS09095 1891493..1892422 + 930 WP_000803360.1 LysR family transcriptional regulator -
JL014_RS09100 1892637..1892699 + 63 WP_010723108.1 membrane protein YoeI -
JL014_RS09105 1892689..1894047 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JL014_RS09110 1894226..1895284 + 1059 WP_000492305.1 transport protein YeeE -
JL014_RS09115 1895298..1895525 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290098 WP_000767829.1 NZ_LR883006:1890286-1890540 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290098 WP_001259255.1 NZ_LR883006:1890038-1890289 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References