Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600186..600985 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag JL014_RS02910 Protein ID WP_000347267.1
Coordinates 600186..600650 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JL014_RS02915 Protein ID WP_001307405.1
Coordinates 600650..600985 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS02880 595187..595621 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JL014_RS02885 595639..596517 - 879 WP_001355782.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JL014_RS02890 596507..597286 - 780 WP_000406212.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JL014_RS02895 597297..597770 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JL014_RS02900 597793..599073 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
JL014_RS02905 599322..600131 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JL014_RS02910 600186..600650 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JL014_RS02915 600650..600985 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JL014_RS02920 601134..602705 - 1572 WP_001273741.1 galactarate dehydratase -
JL014_RS02925 603080..604414 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JL014_RS02930 604430..605200 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T290093 WP_000347267.1 NZ_LR883006:c600650-600186 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT290093 WP_001307405.1 NZ_LR883006:c600985-600650 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References