Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4091387..4091928 Replicon chromosome
Accession NZ_LR882997
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag JL022_RS20115 Protein ID WP_000615976.1
Coordinates 4091650..4091928 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JL022_RS20110 Protein ID WP_000729704.1
Coordinates 4091387..4091647 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS20085 4087170..4087955 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
JL022_RS20090 4087927..4089639 + 1713 Protein_3935 flagellar biosynthesis protein FlhA -
JL022_RS20095 4089744..4090022 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
JL022_RS20100 4090015..4090371 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
JL022_RS20105 4090428..4091201 - 774 WP_122996850.1 C40 family peptidase -
JL022_RS20110 4091387..4091647 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JL022_RS20115 4091650..4091928 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JL022_RS20120 4092084..4092824 + 741 WP_001225679.1 murein L,D-transpeptidase -
JL022_RS20125 4092795..4093562 - 768 WP_000333380.1 class II glutamine amidotransferase -
JL022_RS20130 4093768..4094346 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T290074 WP_000615976.1 NZ_LR882997:4091650-4091928 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT290074 WP_000729704.1 NZ_LR882997:4091387-4091647 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References