Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1960053..1960555 Replicon chromosome
Accession NZ_LR882997
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JL022_RS09475 Protein ID WP_000767835.1
Coordinates 1960301..1960555 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JL022_RS09470 Protein ID WP_001259255.1
Coordinates 1960053..1960304 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS09445 1955230..1956297 - 1068 WP_000080072.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JL022_RS09450 1956297..1957367 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
JL022_RS09455 1957364..1958668 - 1305 WP_001356284.1 histidinol dehydrogenase -
JL022_RS09460 1958674..1959573 - 900 WP_000131774.1 ATP phosphoribosyltransferase -
JL022_RS09465 1959719..1959769 - 51 WP_001364200.1 his operon leader peptide -
JL022_RS09470 1960053..1960304 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JL022_RS09475 1960301..1960555 + 255 WP_000767835.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JL022_RS09480 1960638..1961462 + 825 WP_000754737.1 SDR family oxidoreductase -
JL022_RS09485 1961508..1962437 + 930 WP_000803351.1 LysR family transcriptional regulator -
JL022_RS09490 1962652..1962714 + 63 WP_010723108.1 membrane protein YoeI -
JL022_RS09495 1962704..1964062 + 1359 WP_032327197.1 putrescine/proton symporter PlaP -
JL022_RS09500 1964241..1965299 + 1059 WP_000492320.1 transport protein YeeE -
JL022_RS09505 1965313..1965540 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.51 Da        Isoelectric Point: 7.2751

>T290064 WP_000767835.1 NZ_LR882997:1960301-1960555 [Escherichia coli]
VKLIWSEESWDDYLYWQETDNRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290064 WP_001259255.1 NZ_LR882997:1960053-1960304 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References