Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3912114..3912655 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name yafQ Uniprot ID A0A3W4DAB6
Locus tag JLZ97_RS18840 Protein ID WP_024171431.1
Coordinates 3912377..3912655 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JLZ97_RS18835 Protein ID WP_000729704.1
Coordinates 3912114..3912374 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS18815 3907826..3908611 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
JLZ97_RS18820 3908583..3910295 + 1713 Protein_3681 flagellar biosynthesis protein FlhA -
JLZ97_RS18825 3910482..3910979 - 498 WP_001612413.1 REP-associated tyrosine transposase RayT -
JLZ97_RS18830 3911155..3911904 - 750 WP_000056850.1 C40 family peptidase -
JLZ97_RS18835 3912114..3912374 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JLZ97_RS18840 3912377..3912655 + 279 WP_024171431.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JLZ97_RS18845 3912811..3913551 + 741 WP_001225679.1 murein L,D-transpeptidase -
JLZ97_RS18850 3913522..3914289 - 768 WP_000333380.1 class II glutamine amidotransferase -
JLZ97_RS18855 3914495..3915073 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10829.68 Da        Isoelectric Point: 10.3349

>T290056 WP_024171431.1 NZ_LR882990:3912377-3912655 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVKPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT290056 WP_000729704.1 NZ_LR882990:3912114-3912374 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W4DAB6

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References