Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3940700..3941241 Replicon chromosome
Accession NZ_LR882978
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag JLZ94_RS19325 Protein ID WP_000615976.1
Coordinates 3940963..3941241 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JLZ94_RS19320 Protein ID WP_000729704.1
Coordinates 3940700..3940960 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS19295 3936483..3937268 - 786 WP_064718014.1 putative lateral flagellar export/assembly protein LafU -
JLZ94_RS19300 3937240..3938952 + 1713 Protein_3782 flagellar biosynthesis protein FlhA -
JLZ94_RS19305 3939057..3939335 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
JLZ94_RS19310 3939328..3939684 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
JLZ94_RS19315 3939741..3940514 - 774 WP_000543897.1 C40 family peptidase -
JLZ94_RS19320 3940700..3940960 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JLZ94_RS19325 3940963..3941241 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JLZ94_RS19330 3941397..3942137 + 741 WP_001225679.1 murein L,D-transpeptidase -
JLZ94_RS19335 3942108..3942875 - 768 WP_000333380.1 class II glutamine amidotransferase -
JLZ94_RS19340 3943081..3943659 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T290034 WP_000615976.1 NZ_LR882978:3940963-3941241 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT290034 WP_000729704.1 NZ_LR882978:3940700-3940960 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References