Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1984475..1984977 Replicon chromosome
Accession NZ_LR882978
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JLZ94_RS09725 Protein ID WP_000767829.1
Coordinates 1984723..1984977 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JLZ94_RS09720 Protein ID WP_001259255.1
Coordinates 1984475..1984726 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS09695 1979653..1980720 - 1068 WP_000080130.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JLZ94_RS09700 1980720..1981790 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
JLZ94_RS09705 1981787..1983091 - 1305 WP_001356062.1 histidinol dehydrogenase -
JLZ94_RS09710 1983097..1983996 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JLZ94_RS09715 1984142..1984192 - 51 WP_001364200.1 his operon leader peptide -
JLZ94_RS09720 1984475..1984726 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JLZ94_RS09725 1984723..1984977 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JLZ94_RS09730 1985060..1985884 + 825 WP_000754758.1 SDR family oxidoreductase -
JLZ94_RS09735 1985930..1986859 + 930 WP_000803351.1 LysR family transcriptional regulator -
JLZ94_RS09740 1987074..1987136 + 63 WP_010723108.1 membrane protein YoeI -
JLZ94_RS09745 1987126..1988484 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JLZ94_RS09750 1988663..1989721 + 1059 WP_000492318.1 transport protein YeeE -
JLZ94_RS09755 1989735..1989962 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290026 WP_000767829.1 NZ_LR882978:1984723-1984977 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290026 WP_001259255.1 NZ_LR882978:1984475-1984726 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References