Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 647894..648693 Replicon chromosome
Accession NZ_LR882973
Organism Escherichia coli isolate L2_E1649

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JLZ81_RS03190 Protein ID WP_000347273.1
Coordinates 647894..648358 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JLZ81_RS03195 Protein ID WP_001307405.1
Coordinates 648358..648693 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ81_RS03160 642895..643329 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
JLZ81_RS03165 643347..644225 - 879 WP_001705464.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JLZ81_RS03170 644215..644994 - 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JLZ81_RS03175 645005..645478 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JLZ81_RS03180 645501..646781 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
JLZ81_RS03185 647030..647839 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JLZ81_RS03190 647894..648358 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JLZ81_RS03195 648358..648693 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JLZ81_RS03200 648842..650413 - 1572 WP_001273790.1 galactarate dehydratase -
JLZ81_RS03205 650788..652086 + 1299 WP_001705462.1 galactarate/glucarate/glycerate transporter GarP -
JLZ81_RS03210 652102..652872 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T289998 WP_000347273.1 NZ_LR882973:c648358-647894 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT289998 WP_001307405.1 NZ_LR882973:c648693-648358 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References