Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 776289..776902 Replicon chromosome
Accession NZ_LR882967
Organism Planktothrix pseudagardhii strain No.713

Toxin (Protein)


Gene name graT Uniprot ID A0A1J1LMT6
Locus tag NMK36_RS03260 Protein ID WP_072720388.1
Coordinates 776289..776573 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1J1LP61
Locus tag NMK36_RS03265 Protein ID WP_072720387.1
Coordinates 776588..776902 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK36_RS03245 (NO713_00645) 771527..771712 - 186 WP_072720390.1 hypothetical protein -
NMK36_RS03250 (NO713_00646) 771887..772462 - 576 WP_072720389.1 hypothetical protein -
NMK36_RS03255 (NO713_00647) 772725..775844 - 3120 WP_083580092.1 adenylate/guanylate cyclase domain-containing protein -
NMK36_RS03260 (NO713_00648) 776289..776573 + 285 WP_072720388.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMK36_RS03265 (NO713_00649) 776588..776902 + 315 WP_072720387.1 HigA family addiction module antitoxin Antitoxin
NMK36_RS03270 (NO713_00650) 776937..777059 - 123 Protein_643 Uma2 family endonuclease -
NMK36_RS03275 (NO713_00651) 777214..778944 - 1731 WP_254172976.1 DNA repair protein RecN -
NMK36_RS03280 (NO713_00652) 778996..781821 - 2826 WP_254172977.1 GAF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-57)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11193.72 Da        Isoelectric Point: 9.7480

>T289988 WP_072720388.1 NZ_LR882967:776289-776573 [Planktothrix pseudagardhii]
MPQKYKDKRTAKFAAGDRVKKFQAFERQAYKRLEILEAAPNKESLIALPSNHFEALSGDRKGQYSIRINDKWRICFEWTE
TENRPFNIEIVDYH

Download         Length: 285 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11552.35 Da        Isoelectric Point: 9.8619

>AT289988 WP_072720387.1 NZ_LR882967:776588-776902 [Planktothrix pseudagardhii]
MARPAIHPGEILSDELKELGISASELARSLHIPTNRITQILKGQRGITADTALRLGRWFGTGAELWLNLQKAYELRLAEE
LAGEEIKKTIQPRSSINNQPLVKV

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J1LMT6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J1LP61

References