Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 48017..48539 Replicon plasmid p3
Accession NZ_LR882937
Organism Planktothrix agardhii strain NIVA-CYA126/8

Toxin (Protein)


Gene name graT Uniprot ID A0A073CBU2
Locus tag NMK38_RS22545 Protein ID WP_042158682.1
Coordinates 48017..48259 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A073CAZ7
Locus tag NMK38_RS22550 Protein ID WP_072005276.1
Coordinates 48303..48539 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK38_RS22530 (NIVACYA_04503) 43836..43985 - 150 Protein_27 IS701 family transposase -
NMK38_RS22535 (NIVACYA_04504) 44230..44451 + 222 WP_042158685.1 hypothetical protein -
NMK38_RS22540 (NIVACYA_04505) 44509..47949 + 3441 WP_052369765.1 helicase-related protein -
NMK38_RS22545 (NIVACYA_04506) 48017..48259 + 243 WP_042158682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMK38_RS22550 (NIVACYA_04507) 48303..48539 + 237 WP_072005276.1 HigA family addiction module antitoxin Antitoxin
NMK38_RS22555 (NIVACYA_04508) 48750..51593 + 2844 WP_042158679.1 DUF1156 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90502 90502
- flank IS/Tn - - 43836..43991 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-80)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-78)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9343.78 Da        Isoelectric Point: 10.0912

>T289964 WP_042158682.1 NZ_LR882937:48017-48259 [Planktothrix agardhii]
MIQSFGDKRTEDLFQGISNRETRKFPADLIKVAVRKLDMLNAAYQLEDLRSPPGNRLEALKGDLKGFYSIRINEQWRIIF

Download         Length: 243 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8852.42 Da        Isoelectric Point: 7.2032

>AT289964 WP_072005276.1 NZ_LR882937:48303-48539 [Planktothrix agardhii]
MIKLSMLPRNRIPTHPGEILSEEFLIPLSLTQVALAEHLGVPVQRINEIVKGKRGITPETAWLFAQAFQTSPEFWMNL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A073CBU2

Antitoxin

Source ID Structure
AlphaFold DB A0A073CAZ7

References