Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3554718..3555388 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag JOA04_RS16590 Protein ID WP_003899954.1
Coordinates 3554718..3555062 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag JOA04_RS16595 Protein ID WP_003899955.1
Coordinates 3555059..3555388 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS16560 3549791..3550651 + 861 WP_003416628.1 alpha/beta hydrolase -
JOA04_RS16565 3550626..3551141 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
JOA04_RS16570 3551381..3551674 + 294 WP_003416635.1 hypothetical protein -
JOA04_RS16575 3551962..3553251 + 1290 WP_003416640.1 ATP-binding protein -
JOA04_RS16580 3553598..3554032 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
JOA04_RS16585 3554035..3554487 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JOA04_RS16590 3554718..3555062 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JOA04_RS16595 3555059..3555388 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
JOA04_RS16600 3555750..3557011 + 1262 WP_105799563.1 IS3-like element IS987 family transposase -
JOA04_RS16605 3557284..3557631 + 348 WP_003899956.1 DUF2384 domain-containing protein -
JOA04_RS16610 3557628..3558248 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
JOA04_RS16615 3558408..3559673 - 1266 WP_003909837.1 hypothetical protein -
JOA04_RS16620 3559841..3560050 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T289955 WP_003899954.1 NZ_LR882500:3554718-3555062 [Mycobacterium tuberculosis variant microti]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT289955 WP_003899955.1 NZ_LR882500:3555059-3555388 [Mycobacterium tuberculosis variant microti]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References